Harley Quinn (DC Animated Universe)

Harley's Holiday
As she holds on to the straw of a billboard cola bottle, she talks directly to the viewer about "going out on a joke".

Catsitter
Before the tree branch she is sitting on fully breaks, she briefly looks to the camera as she squeals.

Gotham Noir
After she finishes her story, she looks to the camera, saying "See? Anyone can write this stuff!"